Fisher S J, Damsky C H
Department of Stomatology, University of California San Francisco 94143-0512.
Semin Cell Biol. 1993 Jun;4(3):183-8. doi: 10.1006/scel.1993.1022.
During early pregnancy, fetal chorionic villi that contact the uterine wall give rise to columns of mononuclear cytotrophoblasts that penetrate the superficial portion of the uterus. From these columns emanate cytotrophoblasts that invade deeply into the uterus and its arterioles. To investigate the molecular basis of this unusual, regulated invasive behavior, we used a combination of approaches that included an in vitro model of cytotrophoblast invasion and immunocytochemistry on uterine biopsy sections containing invading cytotrophoblasts. Our results showed interesting roles for: matrix-degrading metalloproteinases, adhesion receptors and their extracellular matrix ligands, and the class I molecule HLA-G.
在妊娠早期，与子宫壁接触的胎儿绒毛膜滋养层会产生单核细胞滋养层细胞柱，这些细胞柱会穿透子宫的表层。从这些细胞柱中发出的细胞滋养层细胞会深入侵入子宫及其小动脉。为了研究这种异常的、受调控的侵袭行为的分子基础，我们采用了多种方法，包括滋养层细胞侵袭的体外模型以及对含有侵袭性细胞滋养层细胞的子宫活检切片进行免疫细胞化学分析。我们的研究结果表明，基质降解金属蛋白酶、黏附受体及其细胞外基质配体以及I类分子HLA - G发挥了有趣的作用。
