Department of Hematology, Nîmes University Hospital, Nîmes, France.
Faculty of Pharmaceutical and Biological Sciences, University of Montpellier, Montpellier, France.
Front Immunol. 2021 Aug 26;12:711394. doi: 10.3389/fimmu.2021.711394. eCollection 2021.
CD146 is an adhesion molecule essentially located in the vascular system, which has been described to play an important role in angiogenesis. A soluble form of CD146, called sCD146, is detected in the bloodstream and is known as an angiogenic factor. During placental development, CD146 is selectively expressed in extravillous trophoblasts. A growing body of evidence shows that CD146 and, in particular, sCD146, regulate extravillous trophoblasts migration and invasion both and . Hereby, we review expression and functions of CD146/sCD146 in the obstetrical field, mainly in pregnancy and in embryo implantation. We emphasized the relevance of quantifying sCD146 in the plasma of pregnant women or in embryo supernatant in the case of fertilization (IVF) to predict pathological pregnancy such as preeclampsia or implantation defect. This review will also shed light on some major results that led us to define CD146/sCD146 as a biomarker of placental development and paves the way toward identification of new therapeutic targets during implantation and pregnancy.
CD146 是一种主要位于血管系统中的黏附分子，它被描述为在血管生成中起重要作用。CD146 的一种可溶性形式，称为 sCD146，可在血液中检测到，被认为是一种血管生成因子。在胎盘发育过程中，CD146 选择性地在绒毛外滋养细胞中表达。越来越多的证据表明，CD146 特别是 sCD146，调节绒毛外滋养细胞的迁移和侵袭。在此，我们综述了 CD146/sCD146 在产科领域的表达和功能，主要是在妊娠和胚胎植入中。我们强调了定量检测孕妇血浆或体外受精 (IVF) 胚胎上清液中 sCD146 的相关性，以预测子痫前期或植入缺陷等病理性妊娠。本综述还将介绍一些重要的结果，这些结果使我们将 CD146/sCD146 定义为胎盘发育的生物标志物，并为在植入和妊娠期间确定新的治疗靶点铺平了道路。
