Goyard S, Sebo P, D'Andria O, Ladant D, Ullmann A
Unité de Biochimie des Régulations Cellulaires, Institut Pasteur, Paris, France.
Zentralbl Bakteriol. 1993 Apr;278(2-3):326-33. doi: 10.1016/s0934-8840(11)80849-2.
The adenylate cyclase toxin of Bordetella pertussis is a secreted multifunctional protein, endowed with calmodulin-activated catalytic, haemolytic and cytotoxic activities. Residues and domains involved in different functions have been localized and several permissive sites, able to accommodate insertion of peptides without impairing the different functions of the toxin, have been identified. A 400-bp region in the promoter upstream region of the cyaA gene, encoding the toxin, has been defined as the target of transcriptional activation.
百日咳博德特氏菌的腺苷酸环化酶毒素是一种分泌型多功能蛋白，具有钙调蛋白激活的催化、溶血和细胞毒性活性。参与不同功能的残基和结构域已被定位，并且已经鉴定出几个允许位点，这些位点能够容纳肽的插入而不损害毒素的不同功能。编码该毒素的cyaA基因启动子上游区域中的一个400 bp区域已被确定为转录激活的靶点。
