细菌黏附与上皮细胞细胞因子产生。
Bacterial adherence and epithelial cell cytokine production.
作者信息
Svanborg C, Agace W, Hedges S, Linder H, Svensson M
机构信息
Dept. of Medical Microbiology, University of Lund, Sweden.
出版信息
Zentralbl Bakteriol. 1993 Apr;278(2-3):359-64.
Epithelial cell lines produce the cytokines IL-1 alpha, IL-6 and IL-8 when stimulated with Escherichia coli. The cytokine response is enhanced by P fimbriae. The epithelial cell lines also respond to stimulation with other cytokines. These in vitro findings were confirmed in vivo in patients with E. coli infection who secreted IL-6 and IL-8 into the urine. The observations suggest that epithelial cells play a more active role in the mucosal immune response than previously recognized.
上皮细胞系在受到大肠杆菌刺激时会产生细胞因子白细胞介素-1α、白细胞介素-6和白细胞介素-8。P菌毛可增强细胞因子反应。上皮细胞系也会对其他细胞因子的刺激作出反应。这些体外研究结果在体内得到了证实，大肠杆菌感染患者的尿液中分泌出白细胞介素-6和白细胞介素-8。这些观察结果表明，上皮细胞在黏膜免疫反应中发挥着比之前认识到的更为积极的作用。
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