Khanina N Ia, Savel'ev V A, Vikulova O V
Eksp Klin Farmakol. 1993 Mar-Apr;56(2):26-8.
The experiments on rats with overload heart failure have shown that creatine phosphate (CP) used in a single dose at the peak of severe signs of cardiac decompensation was found to produce a short-term normalization of rhythm and an increase in heart rate. With multiple doses, the agent slowed down the development of bradycardia, prevented arrhythmias and promoted the rise of longevity in the experimental animals. At the same time, exogenous CP failed to affect energy-dependent processes of re- and depolarization which were impaired in the myocardium in acute heart failure.
对大鼠进行的超负荷心力衰竭实验表明，在心脏失代偿严重症状高峰期单次使用磷酸肌酸（CP），可使心律短期恢复正常并使心率增加。多次给药时，该药物减缓了心动过缓的发展，预防了心律失常，并提高了实验动物的寿命。同时，外源性CP未能影响急性心力衰竭时心肌中受损的再极化和去极化的能量依赖性过程。
