Domnina L V, Fetisova E K, Vasiliev J M
A.N. Belozersky Institute of Physico-Chemical Biology, Moscow State University, Russia.
Cell Biol Int. 1993 Jun;17(6):573-8. doi: 10.1006/cbir.1993.1101.
Co-cultured contacting heterotypic cell groups compete with one another for the attachment to the substratum. In the course of this competition one cell group can progressively push another from the substratum. Alterations to the distribution of cell-associated matrix structures in the course of contact competition were examined by immunomorphological methods in the paired cultures of two epithelial lines and those of fibroblasts and epithelia. It was found that matrix structures formed by the retreating cells withdrew from the substratum simultaneously with the cells. These results show that two forms of matrix structures should be distinguished: the usually immovable matrix upon which the cells crawl and the movable matrix that the cells carry with them when they move.
共培养的接触异型细胞群相互竞争附着于基质。在这种竞争过程中，一个细胞群可以逐渐将另一个细胞群从基质上推开。通过免疫形态学方法，在两种上皮细胞系以及成纤维细胞与上皮细胞的配对培养中，研究了接触竞争过程中细胞相关基质结构分布的变化。结果发现，退缩细胞形成的基质结构与细胞同时从基质上撤离。这些结果表明，应区分两种形式的基质结构：细胞在其上爬行的通常固定不动的基质，以及细胞移动时携带的可移动基质。
