Jinno M, Sugimura K, Kobayashi T, Nozawa S, Itoh S, Takeshita E, Kikuchi H
Department of Obstetrics and Gynecology, School of Medicine, Keio University, Tokyo, Japan.
Int J Fertil Menopausal Stud. 1993 May-Jun;38(3):170-4.
To test the efficacy of a simple criterion--LH level--for administration of hCG in an IVF program.
Prospective, with retrospective analysis of other criteria for hCG administration.
University hospital IVF program.
Eighty-four patients, in 110 cycles, were given 150-300 IU at 10-11 A.M. daily beginning on day 3 of the cycle. Serum LH measured daily 8:30-9:30 A.M., hCG administered on night of day LH level first exceeded J, defined as minimum value + (day 3 value-minimum) x 1/3.
Pregnancy (after IVF + ET); serum concentrations of estradiol and LH.
Total and ongoing pregnancy per cycle: 35% and 27% respectively. If hCG is administered one day early or late by the J criterion, the pregnancy rate is reduced.
Pregnancies occurred over wide follicle diameter (14-21 mm) and estradiol level (229-2,050 pg/mL) ranges. LH is recommended for timing hCG administration.
在体外受精（IVF）程序中，测试一个简单标准——促黄体生成素（LH）水平——用于注射人绒毛膜促性腺激素（hCG）的有效性。
前瞻性研究，对hCG注射的其他标准进行回顾性分析。
大学医院IVF程序。
84名患者，共110个周期，从周期第3天开始，每天上午10点至11点给予150 - 300国际单位。每天上午8点30分至9点30分测量血清LH，当LH水平首次超过J时，在当天晚上注射hCG，J定义为最小值 +（第3天的值 - 最小值）×1/3。
妊娠（IVF + 胚胎移植[ET]后）；雌二醇和LH的血清浓度。
每个周期的总妊娠率和持续妊娠率分别为35%和27%。如果按照J标准提前或推迟一天注射hCG，妊娠率会降低。
在卵泡直径（14 - 21毫米）和雌二醇水平（229 - 2050皮克/毫升）范围较广的情况下都有妊娠发生。建议使用LH来确定hCG的注射时间。
