Sarlis N J, Stephanou A, Knight R A, Lightman S L, Chowdrey H S
Neuroendocrinology Unit, Charing Cross and Westminster Medical School, Charing Cross Hospital, London.
Br J Rheumatol. 1993 Aug;32(8):653-7. doi: 10.1093/rheumatology/32.8.653.
During development of adjuvant arthritis (AA) in the rat, anterior pituitary interleukin-6 (IL-6) mRNA expression was increased. Following adrenalectomy and AA there was a further increase in the accumulation of pituitary IL-6 transcript. Corticosterone (B) replacement in adrenalectomized (ADX) animals resulted in a dose-dependent reduction in pituitary IL-6 mRNA accumulation, while in ADX plus AA animals these effects of B were less marked. Cyclosporine A (CsA) markedly reduced the AA-induced increase in IL-6 mRNA. These data are consistent with an immunologically-mediated activation of pituitary IL-6 mRNA in AA, which may contribute to the increased activity of the pituitary-adrenal axis seen in this condition.
在大鼠佐剂性关节炎（AA）的发展过程中，垂体前叶白细胞介素-6（IL-6）mRNA表达增加。肾上腺切除术后发生AA时，垂体IL-6转录物的积累进一步增加。给肾上腺切除（ADX）的动物补充皮质酮（B）导致垂体IL-6 mRNA积累呈剂量依赖性减少，而在ADX加AA的动物中，B的这些作用不太明显。环孢素A（CsA）显著降低了AA诱导的IL-6 mRNA增加。这些数据与AA中垂体IL-6 mRNA的免疫介导激活一致，这可能导致在这种情况下观察到的垂体-肾上腺轴活性增加。
