腺苷对缺氧豚鼠心脏中乳酸和丙酮酸生成的影响。

Adenosine effect on lactate and pyruvate production in the hypoxic guinea pig heart.

Gutierrez-Juárez R, Madrid-Marina V, Piña E

Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autonoma de México, D.F.

Int J Biochem. 1993 May;25(5):725-9. doi: 10.1016/0020-711x(93)90360-q.

Abstract

It has been shown that adenosine stimulates glycolysis in some cells and this ability of adenosine was tested in the hypoxic guinea pig heart. 2. Adenosine (10 microM) activated lactate production in the isolated perfused guinea pig heart under conditions of normoxia but did not under hypoxia. 3. Despite this, the nucleoside favorably influenced the energy metabolism of the hypoxic heart as revealed by the better posthypoxic functional recovery (98%) compared to the control without adenosine (78%). 4. Our findings suggest a role for the glycolytic pathway in this effect of the nucleoside as long as other cardiac energy-yielding pathways are strictly aerobic.

摘要

已经表明，腺苷在某些细胞中刺激糖酵解，并且在缺氧的豚鼠心脏中测试了腺苷的这种能力。2. 腺苷（10微摩尔）在常氧条件下可激活离体灌注的豚鼠心脏中的乳酸生成，但在缺氧条件下则不能。3. 尽管如此，与未使用腺苷的对照组（78%）相比，该核苷能更好地促进缺氧后心脏功能恢复（98%），从而对缺氧心脏的能量代谢产生有利影响。4. 我们的研究结果表明，只要其他心脏产能途径严格依赖有氧代谢，糖酵解途径在该核苷的这种作用中发挥了作用。