Chun M H, Han S H, Chung J W, Wässle H
Department of Anatomy, Catholic University Medical College, Seoul, Korea.
J Comp Neurol. 1993 Jun 22;332(4):421-32. doi: 10.1002/cne.903320404.
Two immunocytochemical markers were used to label the rod pathway of the rat retina. Rod bipolar cells were stained with antibodies against protein kinase C and AII-amacrine cells with antibodies against parvalbumin. The synaptic circuitry of rod bipolars in the inner plexiform layer (IPL) was studied. Rod bipolar cells make approximately 15 ribbon synapses (dyads) in the IPL. Both postsynaptic members of the dyads are amacrine cells; one is usually the process of an AII-amacrine cell and the other one frequently provides a reciprocal synapse. No direct output from rod bipolar cells into ganglion cells was found. AII-amacrine cells make chemical output synapses with cone bipolar cells and ganglion cells in sublamina a of the IPL. They make gap junctions with cone bipolar cells and other AII-amacrine cells in sublamina b of the IPL. The rod pathway of the rat retina is practically identical to that of the cat and of the rabbit retina. It is very likely that this circuitry is a general feature of mammalian retinal organization.
使用两种免疫细胞化学标记物标记大鼠视网膜的视杆细胞通路。用抗蛋白激酶C抗体对视杆双极细胞进行染色，用抗小白蛋白抗体对AII无长突细胞进行染色。研究了内网状层（IPL）中视杆双极细胞的突触回路。视杆双极细胞在IPL中形成约15个带状突触（双联突触）。双联突触的两个突触后成员均为无长突细胞；一个通常是AII无长突细胞的突起，另一个则经常提供一个反向突触。未发现视杆双极细胞向神经节细胞的直接输出。AII无长突细胞在IPL的a亚层与视锥双极细胞和神经节细胞形成化学输出突触。它们在IPL的b亚层与视锥双极细胞和其他AII无长突细胞形成缝隙连接。大鼠视网膜的视杆细胞通路实际上与猫和兔视网膜的视杆细胞通路相同。很可能这种回路是哺乳动物视网膜组织的一个普遍特征。
