Christiansen F T, Witt C S, Ciccone E, Townend D, Pende D, Viale D, Abraham L J, Dawkins R L, Moretta L
Department of Clinical Immunology, Royal Perth Hospital, Sir Charles Gairdner Hospital, Western Australia.
J Exp Med. 1993 Sep 1;178(3):1033-9. doi: 10.1084/jem.178.3.1033.
As ancestral haplotypes of the major histocompatibility complex (MHC) appear to define identical MHC haplotypes in unrelated individuals, unrelated individuals sharing the same ancestral haplotype should also share the same NK-defined allospecificities that have recently been shown to map to the human MHC. To test this prediction, multiple cell lines from unrelated individuals sharing the same ancestral haplotypes were tested for the NK-defined allospecificities. It was found that cells sharing the same ancestral haplotypes do have the same NK-defined specificities. Furthermore, the NK-defined phenotype of cells that possess two different ancestral haplotypes can be predicted from the NK-defined phenotypes of unrelated cells that are homozygous for the ancestral haplotypes concerned. Although the group 1 and 2 NK-defined allospecificities can be explained to some extent by HLA-C alleles, evidence is presented that additional genes may modify the phenotype conferred by HLA-C.
由于主要组织相容性复合体（MHC）的祖先单倍型似乎在不相关个体中定义了相同的MHC单倍型，那么共享相同祖先单倍型的不相关个体也应该共享相同的自然杀伤细胞（NK）定义的同种特异性，最近已证明这些同种特异性定位于人类MHC。为了验证这一预测，对来自共享相同祖先单倍型的不相关个体的多个细胞系进行了NK定义的同种特异性检测。结果发现，共享相同祖先单倍型的细胞确实具有相同的NK定义的特异性。此外，拥有两种不同祖先单倍型的细胞的NK定义表型可以从相关祖先单倍型纯合的不相关细胞的NK定义表型中预测出来。虽然1组和2组NK定义的同种特异性在一定程度上可以由HLA - C等位基因解释，但有证据表明，其他基因可能会改变HLA - C赋予的表型。
