人类自然杀伤（NK）细胞同种异体反应性及其与主要组织相容性复合体的关联：祖先单倍型编码特定的NK定义单倍型。
Human natural killer (NK) alloreactivity and its association with the major histocompatibility complex: ancestral haplotypes encode particular NK-defined haplotypes.
作者信息
Christiansen F T, Witt C S, Ciccone E, Townend D, Pende D, Viale D, Abraham L J, Dawkins R L, Moretta L
机构信息
Department of Clinical Immunology, Royal Perth Hospital, Sir Charles Gairdner Hospital, Western Australia.
出版信息
J Exp Med. 1993 Sep 1;178(3):1033-9. doi: 10.1084/jem.178.3.1033.
Abstract
As ancestral haplotypes of the major histocompatibility complex (MHC) appear to define identical MHC haplotypes in unrelated individuals, unrelated individuals sharing the same ancestral haplotype should also share the same NK-defined allospecificities that have recently been shown to map to the human MHC. To test this prediction, multiple cell lines from unrelated individuals sharing the same ancestral haplotypes were tested for the NK-defined allospecificities. It was found that cells sharing the same ancestral haplotypes do have the same NK-defined specificities. Furthermore, the NK-defined phenotype of cells that possess two different ancestral haplotypes can be predicted from the NK-defined phenotypes of unrelated cells that are homozygous for the ancestral haplotypes concerned. Although the group 1 and 2 NK-defined allospecificities can be explained to some extent by HLA-C alleles, evidence is presented that additional genes may modify the phenotype conferred by HLA-C.
摘要
由于主要组织相容性复合体（MHC）的祖先单倍型似乎在不相关个体中定义了相同的MHC单倍型，那么共享相同祖先单倍型的不相关个体也应该共享相同的自然杀伤细胞（NK）定义的同种特异性，最近已证明这些同种特异性定位于人类MHC。为了验证这一预测，对来自共享相同祖先单倍型的不相关个体的多个细胞系进行了NK定义的同种特异性检测。结果发现，共享相同祖先单倍型的细胞确实具有相同的NK定义的特异性。此外，拥有两种不同祖先单倍型的细胞的NK定义表型可以从相关祖先单倍型纯合的不相关细胞的NK定义表型中预测出来。虽然1组和2组NK定义的同种特异性在一定程度上可以由HLA - C等位基因解释，但有证据表明，其他基因可能会改变HLA - C赋予的表型。
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本文引用的文献
1
Generation of allospecific natural killer cells by stimulation across a polymorphism of HLA-C.通过跨越HLA - C多态性进行刺激产生同种特异性自然杀伤细胞。
Science. 1993 May 21;260(5111):1121-4. doi: 10.1126/science.8493555.
2
3
Rejection of marrow allografts: importance of H-2 homozygosity of donor cells.骨髓同种异体移植的排斥反应：供体细胞H-2纯合性的重要性。
Transplantation. 1972 Sep;14(3):289-98. doi: 10.1097/00007890-197209000-00001.
4
C4 allotyping on plasma or serum: application to routine laboratories.血浆或血清中的C4别型分析：在常规实验室中的应用
Hum Immunol. 1988 Mar;21(3):165-71. doi: 10.1016/0198-8859(88)90068-7.
5
6
Specific lysis of allogeneic cells after activation of CD3- lymphocytes in mixed lymphocyte culture.混合淋巴细胞培养中CD3⁻淋巴细胞激活后对同种异体细胞的特异性裂解。
J Exp Med. 1988 Dec 1;168(6):2403-8. doi: 10.1084/jem.168.6.2403.
7
Biology and genetics of hybrid resistance.杂种抗性的生物学与遗传学
Adv Immunol. 1987;41:333-445. doi: 10.1016/s0065-2776(08)60034-6.
8
Some disease-associated ancestral haplotypes carry a polymorphism of TNF.
Hum Immunol. 1989 Oct;26(2):91-7. doi: 10.1016/0198-8859(89)90094-3.
9
Differences in gene copy number carried by different MHC ancestral haplotypes. Quantitation after physical separation of haplotypes by pulsed field gel electrophoresis.不同MHC祖先单倍型所携带的基因拷贝数差异。通过脉冲场凝胶电泳对单倍型进行物理分离后的定量分析。
J Exp Med. 1990 Jun 1;171(6):2101-14. doi: 10.1084/jem.171.6.2101.
10
Hemopoietic histocompatibility (Hh-1) regulatory and structural genes of the f haplotype map to H-2.
Transplantation. 1990 Mar;49(3):633-8. doi: 10.1097/00007890-199003000-00030.
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