Kessel D, Chang C K, Henderson B W
Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI 48201.
J Photochem Photobiol B. 1993 May;18(2-3):177-80. doi: 10.1016/1011-1344(93)80060-m.
The photodynamic therapy (PDT) efficacy of a series of porphyrin dimers linked by methylene groups was evaluated using the radiation-induced fibrosarcoma (RIF) tumor model. Longer chain length led to greater efficacy and increased dimer hydrophobicity. This result was correlated with the persistence of porphyrins in plasma, but not with tissue levels.
