体内氦氖激光照射对大鼠脑内生物胺水平的影响。

Effect of in vivo He-Ne laser irradiation on biogenic amine levels in rat brain.

作者信息

Cassone M C, Lombard A, Rossetti V, Urciuoli R, Rolfo P M

机构信息

Istituto di Farmacologia e Farmacognosia, Facoltà di Farmacia, Università di Torin, Italy.

出版信息

J Photochem Photobiol B. 1993 May;18(2-3):291-4. doi: 10.1016/1011-1344(93)80078-n.

DOI:10.1016/1011-1344(93)80078-n

PMID:8350195

Abstract

In order to elucidate the metabolic modifications induced in rat brain by low power He-Ne laser irradiation in vivo, the variations in the biogenic amine levels in cortex, striatum and hippocampus were studied. Noradrenaline (NA), dopamine (DA) and serotonin (5-HT) were evaluated by HPLC-EC on irradiated rats, untreated rats (controls) and rats which had undergone restraint stress (stressed). The results obtained on groups of four to eight rats assayed individually showed that irradiation caused a strong increase in 5-HT in striatum and hippocampus, a small but significant decrease in NA in cortex, and DA levels were not significantly affected. Restraint stress per se led to a considerable decrease in 5-HT and DA in striatum and hippocampus, but did not significantly alter the NA levels.

摘要

为了阐明低功率氦氖激光体内照射对大鼠脑代谢的影响，研究了皮质、纹状体和海马中生物胺水平的变化。采用高效液相色谱-电化学检测法对照射组大鼠、未处理大鼠（对照组）和经束缚应激处理的大鼠（应激组）的去甲肾上腺素（NA）、多巴胺（DA）和5-羟色胺（5-HT）进行了评估。对每组4至8只单独检测的大鼠所获结果显示，照射使纹状体和海马中的5-HT显著增加，皮质中的NA少量但显著减少，而DA水平未受显著影响。单纯束缚应激导致纹状体和海马中的5-HT和DA显著减少，但未显著改变NA水平。