Robillard P Y, Hulsey T C, Alexander G R, Keenan A, de Caunes F, Papiernik E
Department of Neonatology, University Hospital of Pointe-à-Pitre (French West Indies), Guadeloupe.
J Reprod Immunol. 1993 May;24(1):1-12. doi: 10.1016/0165-0378(93)90032-d.
Few authors have published investigations regarding a possible association between preeclampsia and changing paternity. This study employs an epidemiological approach to explore the relationship between severe preeclampsia and changes in paternity patterns among multigravidae in a Caribbean community (Guadeloupe, French West Indies). Multiparae who were diagnosed with preeclampsia or eclampsia with fetal complications (transfer of their infants in the Neonatal Department) and controls were examined (134 mothers' interviews). Information concerning paternity for the index and previous pregnancies was collected from three groups: women with pregnancy-induced hypertension (PIH); women with chronic hypertension (CH); and a control group consisting of women without hypertension during pregnancy. In 21/34 (61.7%) of PIH mothers, the father of the current pregnancy was different than that of the former, compared to 4/40 (10%) among CH and 10/60 (16.6%) in the controls (P < 0.0001). Moreover, considering three and four consecutive pregnancies, there was a significant trend (P < 0.005 and P < 0.02) for an increase in PIH with having a different father in each successive pregnancy. Patterns of changing paternity were significantly correlated with pregnancy-induced hypertension in multiparae but not with chronic hypertension and controls.
很少有作者发表过关于子痫前期与父亲身份变化之间可能存在关联的调查研究。本研究采用流行病学方法，探讨加勒比地区一个社区（瓜德罗普岛，法属西印度群岛）多产妇中重度子痫前期与父亲身份模式变化之间的关系。对诊断为子痫前期或子痫并伴有胎儿并发症（婴儿转入新生儿科）的经产妇及对照组进行了调查（访谈了134位母亲）。从三组人群中收集了本次及既往妊娠的父亲身份信息：妊娠高血压综合征（PIH）患者；慢性高血压（CH）患者；以及孕期无高血压的对照组女性。在PIH母亲中，21/34（61.7%）本次妊娠的父亲与前次不同，而CH组为4/40（10%），对照组为10/60（16.6%）（P<0.0001）。此外，考虑连续三次和四次妊娠，在每次连续妊娠中父亲不同的情况下，PIH有显著上升趋势（P<0.005和P<0.02）。经产妇中父亲身份变化模式与妊娠高血压综合征显著相关，但与慢性高血压及对照组无关。
