Van de Merwe J, Kamerling R, Arendsen E, Mulder D, Hooijkaas H
Department of Immunology, University Hospital Dijkzigt/Erasmus University, Rotterdam, The Netherlands.
J Rheumatol. 1993 Jun;20(6):962-6.
Patients with interstitial cystitis, a chronic nonbacterial inflammation of the bladder, were investigated for the presence of systemic autoimmune diseases, in particular for Sjögren's syndrome (SS).
Ten patients were included in the study on the basis of a diagnosis of interstitial cystitis according to usual criteria. They underwent clinical and laboratory investigations including those for keratoconjunctivitis (KCS) and focal lymphocytic sialoadenitis (FLS).
In 2 patients both KCS and FLS were present allowing the diagnosis of primary SS according to classification criteria. Additionally, in 6 patients one of the 2 hallmarks of primary SS was present, KCS in 3 and FLS in 3.
Interstitial cystitis is a new example of a disease that occurs in association with SS, supporting the concept that interstitial cystitis is an autoimmune cystitis. The clinical relevance of the finding is that a high index of suspicion for SS is indicated in patients with interstitial cystitis.
对间质性膀胱炎（一种膀胱慢性非细菌性炎症）患者进行系统性自身免疫性疾病检查，尤其检查干燥综合征（SS）。
根据通常标准诊断为间质性膀胱炎的10名患者纳入本研究。他们接受了临床和实验室检查，包括角膜结膜炎（KCS）和局灶性淋巴细胞性涎腺炎（FLS）检查。
2名患者同时存在KCS和FLS，根据分类标准可诊断为原发性SS。此外，6名患者存在原发性SS的2个特征之一，3名患者有KCS，3名患者有FLS。
间质性膀胱炎是一种与SS相关的疾病的新例子，支持间质性膀胱炎是自身免疫性膀胱炎的概念。该发现的临床意义在于，间质性膀胱炎患者对SS的怀疑指数较高。
