Heise E, Görlich M
WITEGA gGmbH, Berlin, FGR.
Neoplasma. 1993;40(1):55-7.
Follow-up of 86 patients for at least 40 months confirmed age dependency of receptor binding capacity in primary breast tumors but not in lymph node metastases. In most cases receptor binding capacity was higher in lymph node metastases than in primary tumors. Prognosis of the disease expressed as percentage of patients who survived and had a disease-free interval is related to receptor binding capacity of the primary tumors investigated. In our investigation, a value of 60 fmol/mg protein seems to be a suitable cut-off value to distinguish between breast cancer patients with good and bad prognosis. Receptor levels of lymph node metastases showed a similar behaviour as those of primary tumors related to percentage of patients who survived, but not to disease-free interval.
对86例患者进行至少40个月的随访，证实原发性乳腺肿瘤中受体结合能力与年龄有关，而在淋巴结转移灶中则不然。在大多数情况下，淋巴结转移灶中的受体结合能力高于原发性肿瘤。以存活且无病间期的患者百分比表示的疾病预后与所研究原发性肿瘤的受体结合能力有关。在我们的研究中，60 fmol/mg蛋白的值似乎是区分预后良好和不良的乳腺癌患者的合适临界值。淋巴结转移灶的受体水平与存活患者的百分比相关时，表现出与原发性肿瘤相似的行为，但与无病间期无关。
