Maciejewski B, Zajusz A, Rota L
Centre of Oncology, M. Sklodowska-Curie, Memorial Institute, Gliwice, Poland.
Neoplasma. 1993;40(3):181-4.
The ROC analysis of optimalization of radiation treatment of cancer of the oral cavity was carried out. Material of 210 patients with squamous cell carcinoma (SCC) of the oral cavity was included into the study. Based on dose-response curves for tumor and late mucosal reactions, iso-utility curves and optimal k values were estimated. Optimal k values decreased from 0.792 to 0.584 with extension of overall treatment time from 35 to 49 days. It may suggest that the planning of additional dose to compensate tumor clonogens repopulation during prolonged treatment time does not improve therapeutic gain in radiotherapy for cancer of the oral cavity. The ROC is a useful model to estimate optimal radiation treatment for a given tumor because it is independent of any arbitrary consensus or theoretical assumption.
对口腔癌放射治疗优化进行了ROC分析。该研究纳入了210例口腔鳞状细胞癌（SCC）患者的资料。基于肿瘤和晚期黏膜反应的剂量反应曲线，估计了等效用曲线和最佳k值。随着总治疗时间从35天延长至49天，最佳k值从0.792降至0.584。这可能表明，在延长治疗时间期间规划额外剂量以补偿肿瘤克隆原细胞再增殖，并不能提高口腔癌放射治疗的治疗增益。ROC是一种有用的模型，可用于估计给定肿瘤的最佳放射治疗，因为它独立于任何任意的共识或理论假设。
