Bodker F S, Ticho B H, Feist R M, Lam T T
Department of Ophthalmology and Visual Sciences, University of Illinois, Chicago 60612.
Ophthalmic Surg. 1993 Jul;24(7):453-7.
Using high-performance liquid chromatography, we compared tissue levels of dexamethasone in the aqueous, vitreous, retina, and choroid of rabbits, 1 and 4 hours following subconjunctival or retrobulbar injection. One hour following injection, dexamethasone levels in all of these tissues were similar in both the subconjunctival and retrobulbar groups. Four hours following injection, the concentrations in the two groups also were similar, except in the choroid, in which the subconjunctival injection yielded significantly lower dexamethasone levels than the retrobulbar injection. Tissue steroid levels were comparable ipsilateral and contralateral to the injected eyes in both treatment groups after 4 hours, except in the retina, in which the levels were lower in the contralateral eye after subconjunctival injection. These data suggest that dexamethasone absorption and delivery is predominantly hematogenous following both subconjunctival and retrobulbar injection, especially in highly vascular tissues, such as the choroid. Hematogenous delivery of dexamethasone appears to peak earlier in the choroid and presumably in other intraocular tissues following subconjunctival injections, while retrobulbar injections provide more steady, long-term delivery.
我们使用高效液相色谱法，比较了兔眼在结膜下或球后注射地塞米松1小时和4小时后，房水、玻璃体、视网膜及脉络膜中的地塞米松组织水平。注射后1小时，结膜下注射组和球后注射组所有这些组织中的地塞米松水平相似。注射后4小时，两组中的浓度也相似，但脉络膜除外，结膜下注射产生的地塞米松水平显著低于球后注射。4小时后，两个治疗组中注射眼同侧和对侧的组织类固醇水平相当，但视网膜除外，结膜下注射后对侧眼中的水平较低。这些数据表明，结膜下和球后注射后，地塞米松的吸收和递送主要是通过血源性途径，尤其是在脉络膜等血管丰富的组织中。结膜下注射后，地塞米松的血源性递送在脉络膜以及可能在其他眼内组织中似乎更早达到峰值，而球后注射则提供更稳定、长期的递送。
