Okumura Y, Ueda T, Mori T, Kitabatake T
Strahlentherapie. 1977 Jan;153(1):35-9.
A model of tumor regression during the course of radiotherapy is presented, which considered the lethal effect of radiation, the elimination of dying cells and the reproduction of surviving cells. The model was applied to multiple lung metastases in a woman, which were treated with different doses per fraction. The regression of tumor volume was measured from chest radiographs which were taken once a week during the treatment. Radiosensitivity of tumor cells estimated by the model was of D0=150 R and n=5. The half life of dying cells in the tumor was 15 days.
提出了一种放疗过程中肿瘤消退的模型，该模型考虑了辐射的致死效应、死亡细胞的清除以及存活细胞的增殖。该模型应用于一名女性的多处肺转移瘤，对其采用了不同的分次剂量进行治疗。通过在治疗期间每周拍摄一次的胸部X光片来测量肿瘤体积的消退情况。由该模型估计的肿瘤细胞放射敏感性为D0 = 150伦琴，n = 5。肿瘤中死亡细胞的半衰期为15天。
