Ernst H, Koppenhagen K, Ziegast J
Strahlentherapie. 1977 Jan;153(1):9-12.
Using nuclear medical techniques, especially that of functional scintigraphy with the gamma camera after injection of 99mTc-pertechnetate, it is possible to objectify dose-dependent radiation effects on the salivary glands: Radiation doses from 500 to 1200 rd lead to a temporary reduction of the capacity to accumulate the 99mTc-pertechnetate. This functional restriction is reversible. With radiation doses of more than 2000 rd there appear irreversible functional disorders being proportional to dosage. Focal doses of about 6000 rd produce a complete loss of the capacity for 99mTc accumulation of the salivary glands. The chronological course of radiation response is characterized by a) an activation of the radionuclide accumulation following ca. 3000 rd in about three weeks, b) a following decrease of the capacity for accumulation of 99mTc, c) a renewed activation after the end of irradiation, and d)the progressive and irreversible loss of function of the salivary glands.
运用核医学技术，尤其是在注射99m锝高锝酸盐后使用伽马相机进行功能闪烁显像，就能够客观呈现唾液腺的剂量依赖性辐射效应：500至1200拉德的辐射剂量会导致99m锝高锝酸盐蓄积能力暂时下降。这种功能受限是可逆的。当辐射剂量超过2000拉德时，会出现与剂量成正比的不可逆功能障碍。约6000拉德的局部剂量会导致唾液腺完全丧失蓄积99m锝的能力。辐射反应的时间进程特点为：a) 在约3周内约3000拉德后放射性核素蓄积激活；b) 随后99m锝蓄积能力下降；c) 照射结束后再次激活；d) 唾液腺功能逐渐且不可逆丧失。
