Klein M, Kaminsky P, Duc M
Service de Médecine J, Centre Hospitalier Régional et Universitaire de Nancy, Hôpitaux de Brabois, Vandoeuvre-lès-Nancy.
Therapie. 1993 Mar-Apr;48(2):97-103.
Immune globulin are extracted from plasma pooled from 1000 or more donors. Each lot should contain at least 90% of intact IgG. Intravenous immune globulin are recommended unequivocally for some diseases: acute autoimmune thrombocytopenic purpura of childhood, autoimmune erythroblastopenia, haemophilia with anti-VIII antibodies, Kawasaki's syndrome, and perhaps, Guillain-Barré syndrome. Nevertheless, this therapy has been reported to be beneficial for more than 35 diseases thought to be produced by immunopathology. Large amounts of immune globulin, such as 400 to 2000 mg/kg are proposed over a period of two to five days. The safety of this treatment, which may be introduced without any special structure, is a very interesting quality of the intravenous immune globulin therapy. However, comparative efficacy against reference therapy, surveillance for long-term positive and adverse effects and cost-effectiveness should be carried out.
免疫球蛋白从1000名或更多献血者的混合血浆中提取。每批产品应至少含有90%的完整IgG。静脉注射免疫球蛋白明确推荐用于某些疾病：儿童急性自身免疫性血小板减少性紫癜、自身免疫性成红细胞减少症、伴有抗VIII抗体的血友病、川崎综合征，或许还有格林-巴利综合征。然而，据报道，这种疗法对超过35种被认为由免疫病理学引起的疾病有益。建议在两到五天内给予大量免疫球蛋白，如400至2000mg/kg。这种无需任何特殊结构即可使用的治疗方法的安全性，是静脉注射免疫球蛋白疗法非常吸引人的一个特性。然而，应进行与参考疗法的疗效对比、长期正副作用监测以及成本效益分析。
