Xu H, Gelband H, McCormack J, Pickoff A S, Stolfi A
Department of Pediatrics, China Medical University, Shenyang, China.
Zhongguo Yao Li Xue Bao. 1993 Mar;14(2):106-9.
In the present study, the responses of neonatal and adult dog hearts to phenylephrine (PE) and phentolamine (PA) were investigated in order to determine the influence of age factors. PA resulted in the slowing of the heart rate, the prolongation of corrected sinus node recovery time, atrial refractory period (ARP), ventricular effective refractory period (VERP), and ventricular functional refractory period (VFRP), and a significant inhibition of conducting tissues in neonatal dogs. In contrast, no such effects were seen in adult dogs. PE had a positive chronotropic effect in neonatal dogs but no such effect in adult dogs. In conclusion, alpha-adrenoceptors played an important excitatory role in the neonatal dog heart.
在本研究中，为了确定年龄因素的影响，对新生犬和成年犬心脏对去氧肾上腺素（PE）和酚妥拉明（PA）的反应进行了研究。PA导致新生犬心率减慢、校正窦房结恢复时间、心房不应期（ARP）、心室有效不应期（VERP）和心室功能不应期（VFRP）延长，以及对传导组织有显著抑制作用。相比之下，成年犬未见此类效应。PE对新生犬有正性变时作用，但对成年犬无此作用。总之，α-肾上腺素受体在新生犬心脏中起重要的兴奋作用。
