Morrow R, Nepps P, McIntosh M
Department of Family Medicine, St. Joseph's Medical Center, Yonkers, NY.
J Am Board Fam Pract. 1993 Jul-Aug;6(4):353-7.
We studied the use of an aversive technique to improve the outcome of smoking-cessation efforts. We hypothesized that a silver acetate mouth spray, which produces a strong aversive taste when cigarettes are smoked, would increase the quit rate among smokers.
Our study was a double-blind, placebo-controlled trial that was carried out in a private family practice office in an urban area. We studied 42 smokers, who were recruited by advertisement and who were motivated to quit by self-report. They were randomly assigned active spray or placebo spray; all were given a written list of behavioral suggestions. The spray was to be used every 2 hours for 3 weeks during which time the subjects were to keep diaries of cigarette smoking and spray use. Biochemical measures (salivary thiocyanate and cotinine) were recorded at entry, at 3 weeks, and at 3 months.
Thirty smokers completed the study. No differences were found between the two groups in quit rate or number of cigarettes smoked.
Silver acetate aversive spray did not increase quit rate among motivated smokers.
我们研究了使用厌恶技术来改善戒烟效果。我们假设，一种醋酸银口腔喷雾剂，在吸烟时会产生强烈的厌恶味道，会提高吸烟者的戒烟率。
我们的研究是一项双盲、安慰剂对照试验，在城市地区的一家私人家庭诊所进行。我们研究了42名吸烟者，他们通过广告招募，并且自我报告有戒烟意愿。他们被随机分配使用活性喷雾剂或安慰剂喷雾剂；所有人都收到了一份行为建议的书面清单。在3周内每2小时使用一次喷雾剂，在此期间受试者要记录吸烟和使用喷雾剂的日记。在研究开始时、3周时和3个月时记录生化指标（唾液硫氰酸盐和可替宁）。
30名吸烟者完成了研究。两组在戒烟率或吸烟数量上没有差异。
醋酸银厌恶喷雾剂并没有提高有戒烟意愿的吸烟者的戒烟率。
