老年人红细胞生成素对缺铁性贫血的反应性降低。

Decreased erythropoietin responsiveness to iron deficiency anemia in the elderly.

作者信息

Nafziger J, Pailla K, Luciani L, Andreux J P, Saint-Jean O, Casadevall N

机构信息

Laboratoire d'Hématologie, Hôpital Charles Foix, Ivry Sur Seine, France.

出版信息

Am J Hematol. 1993 Jul;43(3):172-6. doi: 10.1002/ajh.2830430303.

DOI:10.1002/ajh.2830430303

PMID:8352231

Abstract

The prevalence of anemia in the elderly raises the question of an inappropriate secretion of erythropoietin in response to increased demands. Therefore, the serum erythropoietin concentration of elderly patients (74-95 years) with iron deficiency anemia was measured and compared to that of iron deficiency anemic adults (25-60 years). A lowered erythropoietin secretion in response to anemia was observed in elderly patients in comparison with adults. However, the serum erythropoietin of the anemic elderly was inversely correlated with hemoglobin levels as shown for the anemic adults. The progressive reduction of the renal function observed with aging could explain the decreased capacity of erythropoietin secretion in elderly patients.

摘要

老年人贫血的患病率引发了一个问题，即促红细胞生成素在需求增加时分泌不当。因此，对缺铁性贫血的老年患者（74 - 95岁）的血清促红细胞生成素浓度进行了测量，并与缺铁性贫血的成年人（25 - 60岁）进行了比较。与成年人相比，老年患者对贫血的促红细胞生成素分泌降低。然而，贫血老年人的血清促红细胞生成素与血红蛋白水平呈负相关，这与贫血成年人的情况相同。随着年龄增长观察到的肾功能逐渐减退可以解释老年患者促红细胞生成素分泌能力的下降。