Kwong Y L, Ching L M, Liu H W, Lee C P, Pollock A, Chan L C
University Department of Pathology, Queen Mary Hospital, Hong Kong.
Am J Hematol. 1993 Jul;43(3):212-6.
The translocation (8;21)(q22;q22) is commonly associated with acute myeloid leukemia (AML) M2 according to the French-American-British (FAB) classification. We describe 11 cases of t(8;21) diagnosed by strict FAB criteria. Six cases were diagnosed as AML M2, 3 cases as AML M4, 1 case as refractory anemia with excess of blasts in transformation, and 1 case as Philadelphia chromosome negative chronic myeloid leukemia in acceleration. Translocation (8;21) could thus occur in a wider variety of hematological abnormalities. Accordingly, we propose that t(8;21) may involve different hemopoietic lineages.
根据法美英（FAB）分类，易位（8；21）（q22；q22）通常与急性髓系白血病（AML）M2相关。我们描述了11例根据严格FAB标准诊断的t（8；21）病例。6例被诊断为AML M2，3例为AML M4，1例为转化型原始细胞增多的难治性贫血，1例为加速期费城染色体阴性慢性髓系白血病。因此，易位（8；21）可能发生在更广泛的血液学异常中。据此，我们提出t（8；21）可能涉及不同的造血谱系。
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