Magliulo G, Vingolo G M, Petti R, Cristofari P
Fourth ENT Clinic, La Sapienza University, Rome, Italy.
Ann Otol Rhinol Laryngol. 1993 Aug;102(8 Pt 1):596-9. doi: 10.1177/000348949310200805.
The object of the present study was to evaluate electrophysiologically the therapeutic effect of glycerol on the cochlear function of guinea pigs in which experimental hydrops had been surgically induced. Fifteen albino guinea pigs were used. Each animal was chronically implanted to follow the evolution of hearing. The experimental protocol considered 3 groups of guinea pigs (5 animals each). Group 1 received no drug treatment, while groups 2 and 3 were given glycerol orally at 0.75 and 0.50 g/kg of body weight once a day for 4 months. The audiograms of the animals treated with glycerol showed a statistically significant hearing improvement compared with the control group. Clinically, our results seem to support the view of those who favor the use of glycerol for the medical treatment of Meniere's disease at an early stage.
本研究的目的是通过电生理学方法评估甘油对手术诱导实验性积水的豚鼠耳蜗功能的治疗效果。使用了15只白化豚鼠。每只动物都进行了长期植入以跟踪听力的变化。实验方案分为3组豚鼠（每组5只）。第1组未接受药物治疗，而第2组和第3组每天口服甘油，剂量分别为0.75 g/kg和0.50 g/kg体重，持续4个月。与对照组相比，接受甘油治疗的动物的听力图显示听力有统计学意义的改善。临床上，我们的结果似乎支持那些主张在梅尼埃病早期使用甘油进行药物治疗的人的观点。
