Rigobello M P, Toninello A, Siliprandi D, Bindoli A
Centro Studio Fisiologia dei Mitocondri (CNR), Università di Padova, Italy.
Biochem Biophys Res Commun. 1993 Aug 16;194(3):1276-81. doi: 10.1006/bbrc.1993.1961.
Spermine prevents glutathione release induced in rat liver mitochondria by the combined addition of Ca2+ and phosphate. Spermine also inhibits mitochondrial swelling, membrane potential decrease, oxygen uptake and [14C] sucrose entry stimulated by the above reported agent. Mitochondrial swelling is completely prevented by 25 microM spermine while higher concentrations (100 microM) are required for the full inhibition of glutathione release. Therefore, polyamines decrease the mitochondrial inner membrane permeability and, by preventing mitochondrial glutathione loss, also act as protective agents against oxidative stress.
精胺可防止因同时添加钙离子和磷酸盐而诱导大鼠肝线粒体释放谷胱甘肽。精胺还可抑制上述试剂刺激引起的线粒体肿胀、膜电位降低、氧气摄取以及[14C]蔗糖进入。25微摩尔的精胺可完全防止线粒体肿胀，而完全抑制谷胱甘肽释放则需要更高浓度（100微摩尔）。因此，多胺可降低线粒体内膜通透性，通过防止线粒体谷胱甘肽丢失，还可作为抗氧化应激的保护剂。
