POU 结构域蛋白：发育调节因子的结构与功能

POU-domain proteins: structure and function of developmental regulators.

作者信息

Wegner M, Drolet D W, Rosenfeld M G

机构信息

Howard Hughes Medical Institute, University of California, San Diego, School of Medicine, La Jolla 92093-0648.

出版信息

Curr Opin Cell Biol. 1993 Jun;5(3):488-98. doi: 10.1016/0955-0674(93)90015-i.

DOI:10.1016/0955-0674(93)90015-i

PMID:8352967

Abstract

POU-domain proteins are a group of developmental regulators found in organisms as distant as worm and man. The sequence conservation of the POU-domain has allowed the characterization of increasing numbers of proteins containing the domain, many of which act to control the generation and maintenance of differentiated cell phenotypes in organs as diverse as skin and brain. Analysis of the means by which POU-domain proteins regulate transcription has led to a further understanding of how this group initiates specific developmental programs.

摘要

POU 结构域蛋白是一类发育调节因子，在从蠕虫到人类等多种生物中均有发现。POU 结构域的序列保守性使得越来越多含有该结构域的蛋白质得以被鉴定，其中许多蛋白质在诸如皮肤和大脑等不同器官中发挥作用，控制分化细胞表型的产生和维持。对 POU 结构域蛋白调节转录方式的分析，进一步加深了我们对这一蛋白家族如何启动特定发育程序的理解。