De la Casa L G, Ruiz G, Lubow R E
University of Seville, Spain.
Biol Psychiatry. 1993 May 15;33(10):707-11. doi: 10.1016/0006-3223(93)90120-3.
The relationship between amphetamine-produced dopamine overreactivity and attention to irrelevant stimuli is reflected in an attenuated latent inhibition (LI) effect. This occurs in both animal and human subjects. The present study examines the manner in which this effect in rats is modulated by the duration of stimulus preexposure. A factorial design was used with three levels of stimulus preexposure duration and either amphetamine or saline administration. In addition, there were corresponding groups that did not receive stimulus preexposure. It was found that although amphetamine did indeed abolish LI at short exposure intervals (30 sec), the LI effect was normal for long stimulus preexposure durations (150 sec). The data were discussed in terms of the affects of amphetamine on the processing of irrelevant stimuli and the relationship of such a dysfunctional attentional process to schizophrenia.
苯丙胺引起的多巴胺过度反应与对无关刺激的注意力之间的关系体现在潜伏抑制（LI）效应减弱上。这在动物和人类受试者中均有发生。本研究考察了大鼠中这种效应如何受到刺激预暴露持续时间的调节。采用了析因设计，其中刺激预暴露持续时间有三个水平，并分别给予苯丙胺或生理盐水。此外，还有相应的未接受刺激预暴露的组。结果发现，虽然苯丙胺在短暴露间隔（30秒）时确实消除了LI，但在长刺激预暴露持续时间（150秒）时，LI效应是正常的。从苯丙胺对无关刺激处理的影响以及这种功能失调的注意力过程与精神分裂症的关系方面对数据进行了讨论。
