Swails W S, Bell S J, Bistrian B R, Lewis E J, Pfister D, Forse R A, Kelly S, Blackburn G L
Harvard Medical School, Boston, Massachusetts.
Nutrition. 1993 May-Jun;9(3):211-7.
Current research suggests that a diet high in fish oil may be useful for immunomodulation in hospitalized patients. However, one of the side effects of fish oil is a prolongation of the bleeding time, specifically by reducing platelet aggregability. Although this effect might be beneficial for patients with cardiovascular disease, it would be a potential concern in certain critically ill patients. To address this concern, we conducted a prospective study of platelet aggregation in 16 surgical patients who were randomly assigned to receive either a diet containing 16.5 g of fish oil in 1500 ml (Impact) or usual care (standard enteral formulas devoid of fish oil). Feeding was successfully accomplished in the patient group receiving a diet that provided approximately 14.2 g of fish oil/day for 1 wk without significantly affecting platelet aggregability. Thus, it appears that, over the short term, this dose of fish oil does not alter platelet function in hospitalized surgical patients.
目前的研究表明，富含鱼油的饮食可能有助于住院患者的免疫调节。然而，鱼油的副作用之一是延长出血时间，具体表现为降低血小板聚集能力。尽管这种作用对心血管疾病患者可能有益，但在某些重症患者中却是一个潜在问题。为了解决这一问题，我们对16名手术患者进行了一项关于血小板聚集的前瞻性研究，这些患者被随机分配接受两种饮食之一：一种是在1500毫升中含有16.5克鱼油的饮食（Impact），另一种是常规护理（不含鱼油的标准肠内配方）。接受每天提供约14.2克鱼油的饮食的患者组在1周内成功完成喂养，且未显著影响血小板聚集能力。因此，短期内，这种剂量的鱼油似乎不会改变住院手术患者的血小板功能。
