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发热性黏膜皮肤综合征的病因,特别提及感染和药物的激发作用。

Aetiology of febrile mucocutaneous syndromes with special reference to the provocative role of infections and drugs.

作者信息

Ström J

出版信息

Acta Med Scand. 1977 Jan;201(1-2):131-6. doi: 10.1111/j.0954-6820.1977.tb15668.x.

DOI:10.1111/j.0954-6820.1977.tb15668.x
PMID:835363
Abstract

The survey covers 266 patients with febrile mucocutaneous syndromes. A brief account of the highly varied clinical picture is given. The syndromes constitute an allergic reaction which in most drug-provoked cases appeared as a late immunological reaction of serum disease type; for the rest sensitization had probably often taken place. An allergic disposition could be traced in 34% of the cases. Infections and drugs were the causative factor 235 cases (88.3%). Infections accounted for 25.2% drugs for 36.1% and both together for 27.1%. An account is given of the provocative bacterial and viral infections and of the role of drugs in cases with and without infection. Among the remaining 31 cases an infection and/or drug may have been the provocative agent in 16 (6 %) whereas 15 (5.6%) may have been due to alimentary and other factors.

摘要

该调查涵盖了266例发热性皮肤黏膜综合征患者。文中简要介绍了其高度多样化的临床表现。这些综合征构成一种过敏反应,在大多数药物诱发的病例中表现为血清病型的迟发性免疫反应;其余病例可能常有致敏现象。34%的病例可追溯到过敏体质。感染和药物是235例(88.3%)的致病因素。感染占25.2%,药物占36.1%,两者共同作用占27.1%。文中阐述了诱发疾病的细菌和病毒感染以及药物在有感染和无感染病例中的作用。在其余31例中,感染和/或药物可能是16例(6%)的诱发因素,而15例(5.6%)可能归因于饮食和其他因素。

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引用本文的文献

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Erythema multiforme: clinical spectrum and immunopathogenesis.多形红斑:临床谱与免疫发病机制
Springer Semin Immunopathol. 1981 Jun;4(1):45-53. doi: 10.1007/BF01891884.
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Postgrad Med J. 1985 Mar;61(713):263-4. doi: 10.1136/pgmj.61.713.263.
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