Kohen M, Asherson R A, Gharavi A E, Lahita R G
Saint Luke's-Roosevelt Hospital Center, Columbia University, New York, NY 10019.
Clin Exp Rheumatol. 1993 May-Jun;11(3):323-6.
Steroid induced psychosis in SLE is rare but clinically important, and often difficult to distinguish from lupus cerebritis. We report a patient with SLE who became depressed following an increase in her steroid dosage. Based on her clinical presentation and high levels of antibodies to P ribosomal proteins (both in CSF and serum) a diagnosis of lupus cerebritis was made. Steroid dosage, time intervals, and the duration of mental changes may help in differentiating steroid psychosis from lupus cerebritis. No single laboratory test sufficient to establish a definitive diagnosis of lupus cerebritis is available at the present time. However, elevated levels of antibodies to P ribosomal proteins may assist in confirming the diagnosis of this condition.
系统性红斑狼疮（SLE）中类固醇诱导的精神病很少见，但具有临床重要性，且常难以与狼疮性脑炎区分。我们报告了一名SLE患者，其在类固醇剂量增加后出现抑郁。根据其临床表现以及脑脊液和血清中抗P核糖体蛋白抗体水平升高，诊断为狼疮性脑炎。类固醇剂量、时间间隔和精神变化的持续时间可能有助于区分类固醇性精神病和狼疮性脑炎。目前尚无足以确诊狼疮性脑炎的单一实验室检查。然而，抗P核糖体蛋白抗体水平升高可能有助于确诊此病。
