Wassing H E, Siebelink B M, Luyendijk W
Department of Child and Adolescent Psychiatry, University of Leyden, The Netherlands.
Dev Med Child Neurol. 1993 Sep;35(9):788-97. doi: 10.1111/j.1469-8749.1993.tb11730.x.
Hand preference and functional hand-dominance of 45 spina bifida patients (aged 13 to 25 years) were assessed by means of self-reports on an ordinal scale and a tapping task. Non-right-handedness was more frequent among patients with accompanying progressive hydrocephalus. Left-hand preference was significantly more frequent in this group than in patients without shunts. Non-right-handedness in hydrocephalic patients correlated positively with the estimated degree of pre-operative progress of the hydrocephalus. The apparent failure to establish right-handedness in these patients seemed to reflect a developmental disorder of lateralization, related to a more advanced degree of progressive hydrocephalus at an early age. It is suggested that the disorder may be attributable to dysfunction of the corpus callosum, caused by delay in the development of callosal white matter when the hydrocephalus is in a progressive state.
通过序数尺度的自我报告和敲击任务，对45名脊柱裂患者（年龄在13至25岁之间）的用手偏好和功能性手优势进行了评估。在伴有进行性脑积水的患者中，非右利手更为常见。该组中左利手的发生率明显高于未分流患者。脑积水患者的非右利手与术前脑积水进展程度的估计值呈正相关。这些患者明显未能确立右利手，这似乎反映了一种与早期更严重程度的进行性脑积水相关的大脑半球分化发育障碍。有人认为，这种障碍可能归因于胼胝体功能障碍，这是由脑积水处于进行性状态时胼胝体白质发育延迟所致。
