Saling M M, Berkovic S F, O'Shea M F, Kalnins R M, Darby D G, Bladin P F
Department of Psychology, University of Melbourne, Parkville, Victoria, Australia.
J Clin Exp Neuropsychol. 1993 Jul;15(4):608-18. doi: 10.1080/01688639308402582.
This study retrospectively investigated the effect of left (LHS) versus right (RHS) hippocampal sclerosis on verbal memory, measured by means of the Paired Associate Learning and Logical Memory subtests of the Wechsler Memory Scale (WMS) administered as part of a routine preoperative assessment. Patients were selected for the presence of unilateral hippocampal sclerosis by means of preoperative magnetic resonance imaging (MRI) and postoperative neuropathology. The LHS patients (n = 20) were significantly worse on paired associate learning than RHS patients (n = 18), the performance of RHS patients being consistent with normative standards. In contrast, no laterality effect was seen on the immediate and delayed recall of passages; the evidence suggests that both groups performed at a mildly impaired level. It was suggested that the laterality of verbal memory is conditional upon specific task demands in patients with damage to mesial temporal structures.
本研究通过对作为常规术前评估一部分进行的韦氏记忆量表（WMS）的配对联想学习和逻辑记忆子测验进行测量，回顾性调查了左侧（LHS）与右侧（RHS）海马硬化对言语记忆的影响。通过术前磁共振成像（MRI）和术后神经病理学检查来选择存在单侧海马硬化的患者。左侧海马硬化患者（n = 20）在配对联想学习方面显著差于右侧海马硬化患者（n = 18），右侧海马硬化患者的表现符合正常标准。相比之下，在段落的即时和延迟回忆方面未观察到侧别效应；有证据表明两组的表现均处于轻度受损水平。研究表明，对于内侧颞叶结构受损的患者，言语记忆的侧别效应取决于特定的任务要求。
