Michals M L, Crismon M L, Roberts S, Childs A
College of Pharmacy, University of Texas, Austin 78712.
J Clin Psychopharmacol. 1993 Jun;13(3):198-203.
Clozapine was used to treat nine brain-injured patients with psychotic symptoms or outbursts of rage and aggression refractory to other medications. Verbal and physical aggression decreased markedly in two patients, and one additional patient had a dramatic decrease in bizarre behaviors. Mild improvement occurred in three patients with a decrease in agitation and frequency of auditory hallucinations. Response was indeterminate in three patients because of inadequate length of treatment. The incidence of side effects appeared to be higher than expected, with seizures occurring in two of nine patients. These case reports illustrate that clozapine may be useful in the treatment of psychosis and aggressive behavior after brain injury, despite the occurrence of adverse effects.
氯氮平用于治疗9例脑损伤患者，这些患者有精神病性症状或愤怒及攻击行为发作，且对其他药物治疗无效。两名患者的言语和身体攻击行为显著减少，另有一名患者的怪异行为大幅减少。三名患者有轻度改善，其激越和幻听频率降低。三名患者因治疗时间不足，反应情况不明。副作用发生率似乎高于预期，9名患者中有两名发生癫痫发作。这些病例报告表明，尽管出现了不良反应，但氯氮平可能对治疗脑损伤后的精神病和攻击行为有用。
