Elkhatieb A, Hipskind G, Woerner D, Hayden F G
Department of Otolaryngology, Al-Azhar University, Cairo, Egypt.
J Infect Dis. 1993 Sep;168(3):618-21. doi: 10.1093/infdis/168.3.618.
To determine middle ear pressure (MEP) changes during natural rhinovirus colds, adults with illness for < or = 3 days were tested by digital tympanometer daily for 5 days (study 1) or every other day for 7 days (study 2). Abnormal MEPs (< -50 or > +20 mm H2O) were found in 72% of 36 patients in study 1 (P < .001, vs. baseline of 11%) and 76% of 55 patients in study 2 (P < .001, vs. 15% of 103 healthy controls). Major abnormalities (> or = +100 or < or = -100 mm H2O) were found in 61% of patients in study 1 (P < .001, vs. baseline of 0) and 47% in study 2 (P < .001, vs. control of 5%). MEP abnormalities usually resolved by day 14. Only 1 subject developed clinically apparent otitis media. Earache or respiratory symptom scores did not correlate with MEP abnormalities. These results indicate that natural rhinovirus colds in adults are frequently associated with marked but transient MEP abnormalities.
为确定自然感染鼻病毒感冒期间的中耳压力（MEP）变化，对患病≤3天的成年人，在研究1中每天用数字鼓室计检测5天，在研究2中每隔一天检测7天。研究1中36例患者有72%出现MEP异常（＜-50或＞+20 mm H₂O）（P＜.001，与基线水平11%相比），研究2中55例患者有76%出现异常（P＜.001，与103名健康对照者的15%相比）。研究1中61%的患者出现严重异常（≥+100或≤-100 mm H₂O）（P＜.001，与基线水平0相比），研究2中为47%（P＜.001，与对照组的5%相比）。MEP异常通常在第14天消退。仅1名受试者发生临床上明显的中耳炎。耳痛或呼吸道症状评分与MEP异常无相关性。这些结果表明，成人自然感染鼻病毒感冒常伴有明显但短暂的MEP异常。
