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大量口服元素汞。

Massive oral ingestion of elemental mercury.

作者信息

Lin J L, Lim P S

机构信息

Chang Gung Memorial Hospital, Taiwan, Republic of China.

出版信息

J Toxicol Clin Toxicol. 1993;31(3):487-92. doi: 10.3109/15563659309000417.

DOI:10.3109/15563659309000417
PMID:8355325
Abstract

A 42 year old male, while repairing a sphygmomanometer, intentionally ingested an estimated 3 kg (220 mL) of metallic mercury. During admission, only tremor, irritability, forgetfulness and fatigue were noted. There were no obvious gastrointestinal or hepatic complications. Blood and urine mercury levels were significantly elevated. Most of the metallic mercury was cleared from the gut within 10 days. A few months later, hepatic dysfunction with jaundice developed. Serial investigations did not suggest a viral etiology or alcoholism. Liver function tests and blood and urine mercury levels returned to normal over the next 10 months. The observation suggests that massive and prolonged retention of metallic mercury may facilitate the conversion of metallic, elemental mercury to divalent mercury and its subsequent absorption with development of hepatic dysfunction.

摘要

一名42岁男性在修理血压计过程中,故意摄入了约3千克(220毫升)金属汞。入院时,仅发现有震颤、易怒、健忘和疲劳症状。未出现明显的胃肠道或肝脏并发症。血液和尿液中的汞含量显著升高。大部分金属汞在10天内从肠道清除。几个月后,出现了伴有黄疸的肝功能障碍。系列检查未提示病毒病因或酒精中毒。在接下来的10个月里,肝功能检查以及血液和尿液中的汞含量恢复正常。该观察结果表明,大量且长期留存金属汞可能促使金属汞(元素汞)转化为二价汞,并随后被吸收,进而导致肝功能障碍。

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Massive oral ingestion of elemental mercury.大量口服元素汞。
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引用本文的文献

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Endoscopic management of massive mercury ingestion: A case report.大量汞摄入的内镜治疗:一例报告
Medicine (Baltimore). 2017 Jun;96(22):e6937. doi: 10.1097/MD.0000000000006937.
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Mechanisms involved in the transport of mercuric ions in target tissues.汞离子在靶组织中的转运机制。
Arch Toxicol. 2017 Jan;91(1):63-81. doi: 10.1007/s00204-016-1803-y. Epub 2016 Jul 15.
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Metals, oxidative stress and neurodegeneration: a focus on iron, manganese and mercury.金属、氧化应激与神经退行性变:关注铁、锰和汞。
Neurochem Int. 2013 Apr;62(5):575-94. doi: 10.1016/j.neuint.2012.12.006. Epub 2012 Dec 21.
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Transport of inorganic mercury and methylmercury in target tissues and organs.无机汞和甲基汞在靶组织和器官中的转运。
J Toxicol Environ Health B Crit Rev. 2010;13(5):385-410. doi: 10.1080/10937401003673750.
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Molecular and ionic mimicry and the transport of toxic metals.分子和离子模拟以及有毒金属的转运
Toxicol Appl Pharmacol. 2005 May 1;204(3):274-308. doi: 10.1016/j.taap.2004.09.007.