27例骨髓增生异常综合征（MDS）患者的血液学研究

[Hematological study in 27 patients with myelodysplastic syndrome (MDS)].

作者信息

Arai T, Taoka T, Yamaoka G, Kiuchi H, Kawanishi K

机构信息

Department of Clinical Laboratory, Kagawa Medical School Hospital.

出版信息

Rinsho Byori. 1993 Jan;41(1):107-11.

PMID:8355404

Abstract

The clinical, histologic, and cytogenetic features of myelodysplastic syndrome (MDS) were analyzed in 27 patients consisting of 21 males and 6 females (M: F ratio = 3.5:1) whose median age was 60.9 years. Analysis of the peripheral blood of the patients revealed pancytopenia (8 patients), bicytopenia (12), and cytopenia in one cell lineage (5). The patients had high serum iron value and low UIBC value. More than 20% of all erythroid cells in the bone marrow consisted of ringed sideroblasts in not only RARS patients but also RAEB, CMMoL, and RAEB-T patients. Morphological changes of the bone marrow cells were observed in patients with all types of MDS. Eighty percent and 60% of RAEB and RAEB-T patients, respectively, showed trilineage myelodysplasia. Chromosomal abnormalities were observed in 52% of MDS patients. The rate of leukemic transformation was high in RAEB, CMMoL, and RAEB-T patients.

摘要

对27例骨髓增生异常综合征（MDS）患者的临床、组织学和细胞遗传学特征进行了分析，其中男性21例，女性6例（男：女比例为3.5:1），中位年龄为60.9岁。对患者外周血的分析显示全血细胞减少（8例）、两系血细胞减少（12例）和单系血细胞减少（5例）。患者血清铁值高，未饱和铁结合力值低。不仅在难治性贫血伴环形铁粒幼细胞增多（RARS）患者中，而且在难治性贫血伴原始细胞增多（RAEB）、慢性粒-单核细胞白血病（CMMoL）和难治性贫血伴原始细胞增多转变型（RAEB-T）患者中，骨髓中超过20%的所有红系细胞由环形铁粒幼细胞组成。在所有类型的MDS患者中均观察到骨髓细胞的形态学变化。分别有80%和60%的RAEB和RAEB-T患者表现为三系骨髓发育异常。52%的MDS患者观察到染色体异常。RAEB、CMMoL和RAEB-T患者的白血病转化率高。