Iversen P O, Thing-Mortensen B, Nicolaysen G, Benestad H B
Department of Physiology, University of Oslo, Norway.
Leuk Res. 1993 Aug;17(8):663-8. doi: 10.1016/0145-2126(93)90071-r.
An acute promyelocytic leukemia in the rat (BNML) has been used in model studies on pathogenesis and therapy of human acute myeloid leukemia. The blood supply to bone marrow during BNML development has hitherto not been examined, even though in general, blood flow to hematopoietic tissues might affect drug treatment and marrow transplantation regimes. We measured the perfusion of various organs during the course of the disease in untreated rats and in rats given one injection of cyclophosphamide treatment. Organ perfusion was measured with radioactive microspheres. Blood flow per gram tissue to the bone marrow, bone, spleen, and liver declined gradually during the leukemic progression, thus paralleling the growth of leukemic deposits. Cyclophosphamide treatment retarded, but did not reverse, the decreasing perfusion of these tissues.
大鼠急性早幼粒细胞白血病（BNML）已被用于人类急性髓系白血病发病机制和治疗的模型研究。尽管一般来说，造血组织的血流可能会影响药物治疗和骨髓移植方案，但迄今为止尚未对BNML发展过程中骨髓的血液供应进行检查。我们测量了未治疗大鼠和接受一次环磷酰胺治疗的大鼠在疾病过程中各个器官的灌注情况。使用放射性微球测量器官灌注。在白血病进展过程中，每克组织流向骨髓、骨骼、脾脏和肝脏的血流量逐渐下降，因此与白血病沉积物的生长情况平行。环磷酰胺治疗减缓了这些组织灌注的下降，但并未使其逆转。
