卡贝缩宫素向人母乳中的转移。

Transfer of carbetocin into human breast milk.

作者信息

Silcox J, Schulz P, Horbay G L, Wassenaar W

机构信息

Department of Obstetrics and Gynecology, Victoria Hospital, London, Ontario, Canada.

出版信息

Obstet Gynecol. 1993 Sep;82(3):456-9.

PMID:8355953

Abstract

OBJECTIVE

To study the transfer of carbetocin into human breast milk.

METHODS

Five healthy nursing women, 7-14 weeks postpartum, emptied their breasts using a breast pump and then received 70 micrograms carbetocin by intramuscular injection. Using a radioimmunoassay, the concentrations of carbetocin were measured in plasma and breast milk samples obtained before carbetocin administration and at 15, 30, 60, 90, 120, and 240 minutes after drug administration.

RESULTS

For plasma, the mean (+/- standard deviation) area under the curve (AUC) of carbetocin versus time was 1119.3 +/- 315.9 pg/mL, a value about 50 times higher than the mean AUC for carbetocin in breast milk (18.6 +/- 13.7 and 29.0 +/- 23.8 pg/mL for the right and left breast, respectively). The ratio of milk to plasma AUC was low: 1.7 +/- 0.9 and 3.1 +/- 2.8% for the left and right breast, respectively. No serious adverse reactions occurred and no clinically significant changes in vital signs were found.

CONCLUSION

Very little carbetocin is transferred into human breast milk, presenting little risk to breast-fed infants.

摘要

目的

研究卡贝缩宫素在人母乳中的转移情况。

方法

五名产后7 - 14周的健康哺乳期妇女用吸奶器排空乳房，然后通过肌肉注射接受70微克卡贝缩宫素。采用放射免疫分析法，在给药前以及给药后15、30、60、90、120和240分钟采集的血浆和母乳样本中测量卡贝缩宫素的浓度。

结果

血浆中，卡贝缩宫素浓度 - 时间曲线下的平均（±标准差）面积（AUC）为1119.3 ± 315.9 pg/mL，该值约为母乳中卡贝缩宫素平均AUC的50倍（右侧乳房和左侧乳房的AUC分别为18.6 ± 13.7和29.0 ± 23.8 pg/mL）。母乳与血浆AUC的比值较低：左侧乳房和右侧乳房分别为1.7 ± 0.9%和3.1 ± 2.8%。未发生严重不良反应，生命体征也未出现具有临床意义的变化。