Bakker C M, Stibbe J, Gomes M J, Groenland T N, Metselaar H J, Hesselink E J, Schalm S W, Terpstra O T
Department of Hematology, University Hospital Dijkzigt, Rotterdam, The Netherlands.
Transplantation. 1993 Aug;56(2):327-9. doi: 10.1097/00007890-199308000-00013.
The release of heparin has been mentioned as one of the causes of hypocoagulability after reperfusion of the liver graft. It has been ascribed to endogenous heparin released from the donor liver or to exogenous heparin in the preservation fluid that is released into the recipient after sequestration into the graft during preservation. The aim of this study was to investigate whether systemic administration of heparin to the donor before the hepatectomy contributes to the appearance of heparin in the recipient after reperfusion. We studied 20 patients undergoing an auxiliary heterotopic liver transplantation; 15 donors had received heparin immediately before circulation arrest (median 300 IU/kg body weight), but 5 had not. The thrombin time (TT), activated partial thromboplastin time (aPTT), and heparin neutralization test were determined at several intervals during the transplantation.
肝素的释放被认为是肝移植再灌注后低凝性的原因之一。这归因于供体肝脏释放的内源性肝素，或归因于保存液中的外源性肝素，在保存期间被隔离到移植物中后释放到受体体内。本研究的目的是调查在肝切除术前对供体进行全身肝素给药是否会导致再灌注后受体体内出现肝素。我们研究了20例接受辅助异位肝移植的患者；15例供体在循环停止前立即接受了肝素（中位剂量为300 IU/kg体重），但5例未接受。在移植过程中的几个时间点测定了凝血酶时间（TT）、活化部分凝血活酶时间（aPTT）和肝素中和试验。
