Eppley B L, Holley S, Sadove A M
Plastic and Reconstructive Surgery Section, Indiana University Medical Center, Indianapolis 46202-5200.
Ann Plast Surg. 1993 Jul;31(1):19-26; discussion 26-7.
A skeletal growth study evaluating an intraorbital tissue expander as a globe replacement in anophthalmos was conducted in an infant animal model. Twenty-one 21-day-old kittens were equally divided into the following three groups: a control, a unilaterally enucleated, and an enucleated-expanded group. Postoperative three-dimensional computed tomographic scans were obtained at 5 months of age immediately before study termination. Linear orbital, orbitomaxillary, and zygomaticomaxillary dimensions were measured on the scans and compared at necropsy with orbital volume assessment on the dry skulls. Control animal orbits averaged 21.5 mm in height, 21.0 mm in width, and 5.1 cm3 in orbital volume, and an orbitomaxillary-zygomaticomaxillary height-to-width ratio of 31.0: 24.5. The control side, its contralateral side, and the contralateral orbits of the treated sides were not significantly different. By study completion, enucleation resulted in a significant loss of orbital volume (mean, 1.9 cm3; p < 0.001) confirmed by deficient orbitozygomaticomaxillary measurements. The expanded orbits showed no loss of volume (mean, 5.2 cm3; p > 0.1) and normalization of all linear midfacial structures. This study demonstrates that early expansion emanating from within the orbital soft tissue positively affects both the skeletal and lid anomalies associated with congenital globe loss or early enucleation.
在一个幼小动物模型中进行了一项骨骼生长研究，评估眶内组织扩张器作为无眼球眼眶替代物的效果。21只21日龄的小猫被平均分为以下三组：对照组、单侧眼球摘除组和眼球摘除-扩张组。在研究结束前5个月龄时进行术后三维计算机断层扫描。在扫描上测量线性眶、眶上颌和颧上颌尺寸，并在尸检时与干颅骨上的眼眶体积评估进行比较。对照动物眼眶平均高度为21.5毫米，宽度为21.0毫米，眼眶体积为5.1立方厘米，眶上颌-颧上颌高宽比为31.0:24.5。对照组一侧、其对侧以及治疗侧的对侧眼眶之间无显著差异。到研究完成时，眼球摘除导致眼眶体积显著减少（平均为1.9立方厘米；p<0.001），眶颧上颌测量结果证实了这一点。扩张后的眼眶没有体积减少（平均为5.2立方厘米；p>0.1），并且所有面部中部线性结构恢复正常。这项研究表明，源自眶内软组织的早期扩张对与先天性眼球缺失或早期眼球摘除相关的骨骼和眼睑异常均有积极影响。
