Burns L H, Robbins T W, Everitt B J
Department of Experimental Psychology, University of Cambridge, UK.
Behav Brain Res. 1993 Jun 30;55(2):167-83. doi: 10.1016/0166-4328(93)90113-5.
The experiments reported here have investigated the impact on reward-related processes of lesioning the basolateral amygdala, ventral subiculum and prelimbic cortex which represent the major limbic sources of afferents to the ventral striatum. The results showed that, while lesions of the prelimbic cortex were without effect on the approach to a CS predictive of sucrose reinforcement and the acquisition of a new response with conditioned reinforcement, lesions of the other two structures significantly impaired both responses. However, there were important differences between the effects of basolateral amygdala and ventral subiculum lesions. Thus, lesions of the ventral subiculum completely abolished the locomotor response to intra-accumbens infusions of D-amphetamine, in addition to blocking the potentiative effect of the same treatment on responding with conditioned reinforcement. Lesions of the basolateral amygdala, by contrast, reduced the control over behaviour by a conditioned reinforcer, but not the potentiation of that control by intra-accumbens D-amphetamine except at the highest dose. Moreover, the locomotor response to D-amphetamine-induced increases in dopamine in the nucleus accumbens was unaffected by amygdala lesions over the dose range blocked by ventral subiculum lesions. The results suggest a rather selective effect of amygdala-ventral striatal interactions on processes subserving conditioned reinforcement and a more fundamental influence of ventral subiculum-ventral striatal interactions in mediating the psychomotor stimulant effects of D-amphetamine.
此处报告的实验研究了损毁基底外侧杏仁核、腹侧海马下脚和前边缘皮层对奖赏相关过程的影响，这些结构是腹侧纹状体主要的边缘传入神经来源。结果显示，虽然前边缘皮层的损毁对接近预测蔗糖强化的条件刺激以及通过条件强化获得新反应没有影响，但其他两个结构的损毁显著损害了这两种反应。然而，基底外侧杏仁核和腹侧海马下脚损毁的影响存在重要差异。因此，腹侧海马下脚的损毁除了阻断相同处理对条件强化反应的增强作用外，还完全消除了对伏隔核内注射D-苯丙胺的运动反应。相比之下，基底外侧杏仁核的损毁减少了条件强化物对行为的控制，但除了最高剂量外，并未减弱伏隔核内注射D-苯丙胺对这种控制的增强作用。此外，在腹侧海马下脚损毁所阻断的剂量范围内，杏仁核损毁并未影响对D-苯丙胺诱导的伏隔核多巴胺增加的运动反应。结果表明，杏仁核-腹侧纹状体相互作用对条件强化过程具有相当选择性的影响，而腹侧海马下脚-腹侧纹状体相互作用在介导D-苯丙胺的精神运动兴奋作用方面具有更根本的影响。
