Robledo P, Robbins T W, Everitt B J
Department of Experimental Psychology, University of Cambridge, United Kingdom.
Behav Neurosci. 1996 Oct;110(5):981-90. doi: 10.1037//0735-7044.110.5.981.
The present study examined the effects of lesions of the central nucleus of the amygdala (CeA) on the acquisition of a new response with conditioned reinforcement (CR) and its potentiation by intra-accumbens infusions of d-amphetamine (1, 3, 10, and 20 microg/microl). Rats were trained to associate a light-plus-noise compound stimulus with the availability of a sucrose solution before receiving both bilateral ibotenic acid lesions of the CeA and cannulas implanted above the nucleus accumbens. Lesions of the central nucleus did not impair the performance of positively reinforced discriminated approach, nor did they impair the acquisition of a new response with conditioned reinforcement. However, the potentiation of responding with CR following intra-accumbens amphetamine was blocked in lesioned animals. These results are discussed in terms of the possible interactions between associative mechanisms in the amygdala and the mesolimbic dopamine projection.
本研究考察了杏仁核中央核（CeA）损伤对通过条件强化（CR）获得新反应及其被伏隔核内注射d-苯丙胺（1、3、10和20微克/微升）增强的影响。在接受CeA双侧异搏定酸损伤和在伏隔核上方植入套管之前，训练大鼠将光加噪声复合刺激与蔗糖溶液的可得性联系起来。中央核损伤并未损害阳性强化辨别性接近行为的表现，也未损害通过条件强化获得新反应的能力。然而，在损伤动物中，伏隔核内注射苯丙胺后CR反应的增强被阻断。根据杏仁核和中脑边缘多巴胺投射中的联想机制之间可能的相互作用对这些结果进行了讨论。
