Iyer M, Gorevic P D
Department of Medicine, SUNY, Stony Brook 11794-8161.
Curr Opin Rheumatol. 1993 Jul;5(4):475-82. doi: 10.1097/00002281-199305040-00012.
The spectrum of arthropathy in non-HIV immune deficiency states includes arthritis due to prevalent infectious pathogens and autoimmunity that may in some instances be triggered by microorganisms. Joint symptoms may be clinical manifestations of disease, or they may develop later during therapy for immunodeficiency. Pathogenesis can be related to occult infection, loss of mucosal barrier function, defective clearance of immune complexes, or aberrant immune responses. Proper treatment includes an appreciation of likely pathogens, an understanding of the nature of immunologic deficits, and rigorous exclusion of immune dysfunction that may be secondary to treatment.
非HIV免疫缺陷状态下的关节病谱包括由常见感染性病原体引起的关节炎以及自身免疫性疾病，在某些情况下自身免疫性疾病可能由微生物触发。关节症状可能是疾病的临床表现，也可能在免疫缺陷治疗过程中出现。发病机制可能与隐匿性感染、黏膜屏障功能丧失、免疫复合物清除缺陷或异常免疫反应有关。恰当的治疗包括了解可能的病原体、理解免疫缺陷的本质以及严格排除可能继发于治疗的免疫功能障碍。
