Gout and mechanisms of crystal-induced inflammation.

Since last year's review of gout and hyperuricemia, investigators have described new potential mechanisms that may contribute to urate crystal deposition and the propagation, self-limitation, and therapeutic control of gouty inflammation. The clinical presentation of gout in women continues to be described in greater detail. Also, new information on oral allopurinol desensitization is now available to help approach the difficult problem of allopurinol hypersensitivity.