Tsujitani S, Kakeji Y, Maehara Y, Sugimachi K, Kaibara N
Department of Surgery, School of Medicine, Tottori University Yonago, Japan.
In Vivo. 1993 May-Jun;7(3):233-7.
Infiltration of S-100 protein positive dendritic cells into tumor tissues was investigated immunohistochemically. Although the survival time of patients with Stage I, II or IV gastric cancer did not relate to the density of dendritic cells, survival time in Stage III patients correlated with the density of dendritic cells. In patients with a marked infiltration, survival time was longer than in cases of only a slight infiltration (P < 0.001). The frequency in the marked infiltration group at the mucosal stage did not change in proportion to invasion into the deeper layers. There was a similar incidence of lymph node metastasis between the marked and slight infiltration groups in each grade of tumor invasion. However, marked infiltration of dendritic cells prevented widespread nodal involvement beyond the primary node in cases of advanced cancer (P < 0.05). This may be one of the reasons why the infiltration of dendritic cells is clinically effective in patients with Stage III gastric cancer.
采用免疫组织化学方法研究了S-100蛋白阳性树突状细胞在肿瘤组织中的浸润情况。虽然I期、II期或IV期胃癌患者的生存时间与树突状细胞密度无关，但III期患者的生存时间与树突状细胞密度相关。在浸润明显的患者中，生存时间长于浸润轻微的患者（P<0.001）。黏膜期浸润明显组的频率并不随浸润至更深层而按比例变化。在各肿瘤浸润分级中，浸润明显组和轻微组之间的淋巴结转移发生率相似。然而，在进展期癌症病例中，树突状细胞的明显浸润可防止淋巴结广泛受累超出初级淋巴结（P<0.05）。这可能是树突状细胞浸润对III期胃癌患者具有临床疗效的原因之一。
