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1,25-Dihydroxyvitamin D3 upregulates 5-lipoxygenase metabolism and 5-lipoxygenase activating protein in peripheral blood monocytes as they differentiate into mature macrophages.

作者信息

Coffey M J, Gyetko M, Peters-Golden M

机构信息

University of Michigan, Division of Pulmonary Medicine, Ann Arbor 48109-0360.

出版信息

J Lipid Mediat. 1993 Mar-Apr;6(1-3):43-51.

PMID:8358002
Abstract
摘要

相似文献

1
1,25-Dihydroxyvitamin D3 upregulates 5-lipoxygenase metabolism and 5-lipoxygenase activating protein in peripheral blood monocytes as they differentiate into mature macrophages.1,25-二羟维生素D3上调外周血单核细胞分化为成熟巨噬细胞过程中的5-脂氧合酶代谢及5-脂氧合酶激活蛋白。
J Lipid Mediat. 1993 Mar-Apr;6(1-3):43-51.
2
Increases in 5-lipoxygenase activating protein expression account for enhanced capacity for 5-lipoxygenase metabolism that accompanies differentiation of peripheral blood monocytes into alveolar macrophages.5-脂氧合酶激活蛋白表达的增加解释了外周血单核细胞分化为肺泡巨噬细胞时伴随的5-脂氧合酶代谢能力增强的现象。
Am J Respir Cell Mol Biol. 1994 Aug;11(2):153-8. doi: 10.1165/ajrcmb.11.2.8049076.
3
Reduced 5-lipoxygenase metabolism of arachidonic acid in macrophages rrom 1,25-dihydroxyvitamin D3-deficient rats.1,25 - 二羟基维生素D3缺乏大鼠巨噬细胞中花生四烯酸的5 - 脂氧合酶代谢降低。
Prostaglandins. 1994 Nov;48(5):313-29. doi: 10.1016/0090-6980(94)90031-0.
4
Human monocytes lose 5-lipoxygenase and FLAP as they mature into monocyte-derived macrophages in vitro.在体外，人类单核细胞成熟为单核细胞衍生的巨噬细胞时会失去5-脂氧合酶和FLAP。
Am J Physiol. 1996 Jul;271(1 Pt 1):C372-7. doi: 10.1152/ajpcell.1996.271.1.C372.
5
Regulation of the expression of 5-lipoxygenase-activating protein/5-lipoxygenase and the synthesis of leukotriene B(4) in osteoarthritic chondrocytes: role of transforming growth factor beta and eicosanoids.骨关节炎软骨细胞中5-脂氧合酶激活蛋白/5-脂氧合酶表达的调控及白三烯B4的合成：转化生长因子β和类花生酸的作用
Arthritis Rheum. 2004 Dec;50(12):3925-33. doi: 10.1002/art.20632.
6
Alveolar lining fluid regulates mononuclear phagocyte 5-lipoxygenase metabolism.肺泡衬液调节单核吞噬细胞5-脂氧合酶代谢。
Eur Respir J. 1998 Nov;12(5):1141-6. doi: 10.1183/09031936.98.12051141.
7
IL-4 determines eicosanoid formation in dendritic cells by down-regulation of 5-lipoxygenase and up-regulation of 15-lipoxygenase 1 expression.白细胞介素-4通过下调5-脂氧合酶和上调15-脂氧合酶1的表达来决定树突状细胞中类花生酸的形成。
Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):5152-7. doi: 10.1073/pnas.091076998.
8
Signaling of monocytic differentiation by a non-hypercalcemic analog of vitamin D3, 1,25(OH)2-5,6 trans-16-ene-vitamin D3, involves nuclear vitamin D receptor (nVDR) and non-nVDR-mediated pathways.维生素D3的一种非高钙血症类似物1,25(OH)2-5,6反式-16-烯-维生素D3介导的单核细胞分化信号传导涉及核维生素D受体(nVDR)和非nVDR介导的途径。
J Cell Physiol. 2002 May;191(2):198-207. doi: 10.1002/jcp.10091.
9
Differential regulation of cyclo-oxygenase-2 and 5-lipoxygenase-activating protein (FLAP) expression by glucocorticoids in monocytic cells.糖皮质激素对单核细胞中环氧化酶-2和5-脂氧合酶激活蛋白（FLAP）表达的差异调节
Br J Pharmacol. 1997 Oct;122(4):619-24. doi: 10.1038/sj.bjp.0701425.
10
Hyperoxia increases protein mass of 5-lipoxygenase and its activating protein, flap, and leukotriene B(4) output in newborn rat lungs.高氧增加新生大鼠肺中5-脂氧合酶及其激活蛋白flap的蛋白质含量以及白三烯B4的生成量。
Exp Lung Res. 2002 Dec;28(8):671-84. doi: 10.1080/01902140260426751.

引用本文的文献

1
Post-transcriptional regulation of 5-lipoxygenase mRNA expression via alternative splicing and nonsense-mediated mRNA decay.通过选择性剪接和无意义介导的 mRNA 降解对 5-脂氧合酶 mRNA 表达的转录后调控。
PLoS One. 2012;7(2):e31363. doi: 10.1371/journal.pone.0031363. Epub 2012 Feb 21.
2
Sequential induction of 5-lipoxygenase gene expression and activity in Mono Mac 6 cells by transforming growth factor beta and 1,25-dihydroxyvitamin D3.转化生长因子β和1,25 - 二羟基维生素D3对Mono Mac 6细胞中5 - 脂氧合酶基因表达和活性的顺序诱导作用
Proc Natl Acad Sci U S A. 1995 Jan 3;92(1):107-11. doi: 10.1073/pnas.92.1.107.
3
5-Lipoxygenase is located in the euchromatin of the nucleus in resting human alveolar macrophages and translocates to the nuclear envelope upon cell activation.
5-脂氧合酶位于静息人肺泡巨噬细胞核的常染色质中，细胞活化时会转移至核膜。
J Clin Invest. 1995 May;95(5):2035-46. doi: 10.1172/JCI117889.
4
Migration of human inflammatory cells into the lung results in the remodeling of arachidonic acid into a triglyceride pool.人类炎症细胞向肺部的迁移导致花生四烯酸重塑为甘油三酯池。
J Exp Med. 1995 Nov 1;182(5):1181-90. doi: 10.1084/jem.182.5.1181.