Rodríguez Sanjuán J C, Val Bernal F, Blanco García C, García-Castrillo Riesgo L
Department of Pathology, University Hospital Marqués de Valdecilla, Faculty of Medicine, Santander, Spain.
Histol Histopathol. 1993 Jul;8(3):505-8.
In order to determine the possible influence in oesophageal squamous cell carcinoma of nuclear measurements on patients' postoperative survival and on various histological tumour features, we performed a nuclear morphometry study on 53 patients (50 males, 3 females) with a mean age of 57.4 years (37-79). A statistical correlation was revealed between area, perimeter and diameter and the analysis was, therefore, performed only in terms of nuclear area. No influence of nuclear area on postoperative survival was observed. Nor was a relationship found between mean nuclear area and either involvement of the oesophageal wall or degree of histological differentiation. The tumours showing expansive growth had a larger mean nuclear area than those of the infiltrative growth type, although differences did not reach statistical significance. The nuclear area standard deviation (reflecting anisocytosis of the tumour) showed no correlation with survival. In conclusion, our data do not support that measurement of nuclear parameters by static methods is of any prognostic value in surgically-treated squamous cell carcinoma of the oesophagus.
为了确定细胞核测量对食管鳞状细胞癌患者术后生存及各种组织学肿瘤特征可能产生的影响，我们对53例患者（50例男性，3例女性）进行了细胞核形态计量学研究，这些患者的平均年龄为57.4岁（37 - 79岁）。研究发现面积、周长和直径之间存在统计学相关性，因此仅依据细胞核面积进行了分析。未观察到细胞核面积对术后生存有影响。平均细胞核面积与食管壁受累情况或组织学分化程度之间也未发现关联。呈膨胀性生长的肿瘤其平均细胞核面积大于浸润性生长类型的肿瘤，尽管差异未达到统计学意义。细胞核面积标准差（反映肿瘤的细胞大小不均一性）与生存无相关性。总之，我们的数据不支持通过静态方法测量细胞核参数对手术治疗的食管鳞状细胞癌具有任何预后价值。
