Włostowski T
Institute of Biology, Warsaw University, Białystok, Poland.
Biometals. 1993 Summer;6(2):71-6. doi: 10.1007/BF00140106.
Metallothionein is a low-molecular weight, cysteine-rich, metal-binding protein which has been implicated in the detoxification of toxic metals (cadmium, mercury), metabolism of zinc and copper, as well as in the scavenging of free radicals. Recent evidence suggests that the protein may also be involved in cell proliferation. Based on the experiments carried out so far, it is assumed that the fundamental role of metallothionein in cell proliferation may be to detoxify and/or transfer copper ions from the cytoplasm to the nucleus at the G1/S phase, which in turn participate in some way in nuclear DNA synthesis.
金属硫蛋白是一种低分子量、富含半胱氨酸的金属结合蛋白，它与有毒金属（镉、汞）的解毒、锌和铜的代谢以及自由基的清除有关。最近的证据表明，该蛋白也可能参与细胞增殖。根据目前所进行的实验，推测金属硫蛋白在细胞增殖中的基本作用可能是在G1/S期将铜离子从细胞质解毒和/或转运至细胞核，而铜离子进而以某种方式参与核DNA合成。
